Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53

The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide information about p53-target gene regulation has been derived mostly from acut...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Kirschner, Kristina, Samarajiwa, Shamith A., Cairns, Jonathan M., Menon, Suraj, Pérez-Mancera, Pedro A., Tomimatsu, Kosuke, Bermejo-Rodriguez, Camino, Ito, Yoko, Chandra, Tamir, Narita, Masako, Lyons, Scott K., Lynch, Andy G., Kimura, Hiroshi, Ohbayashi, Tetsuya, Tavaré, Simon, Narita, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366240/
https://ncbi.nlm.nih.gov/pubmed/25790137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005053
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