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Knockdown of Glutamate Cysteine Ligase Catalytic Subunit by siRNA Causes the Gold Nanoparticles-Induced Cytotoxicity in Lung Cancer Cells

Gold nanoparticles (GNPs) have shown promising medical applications in cancer treatment involved in the regulation of intracellular redox balance. Previously, we have reported that GNPs can trigger apoptosis and necrosis in human lung cancer cells (A549) when L-buthionine-sulfoximine (BSO) was used...

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Veröffentlicht in:PLoS One
Hauptverfasser: Liu, Min, Zhao, Yunxue, Zhang, Xiumei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366198/
https://ncbi.nlm.nih.gov/pubmed/25789740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118870
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