IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis (Mtb) infection. Evidence suggests that IL-4/IL-13 alternatively activated macrophages (aaMph or M2) are exploited by Mtb to divert microbicidal functions of caMph. To define the funct...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Guler, Reto, Parihar, Suraj P., Savvi, Suzana, Logan, Erin, Schwegmann, Anita, Roy, Sugata, Nieuwenhuizen, Natalie E., Ozturk, Mumin, Schmeier, Sebastian, Suzuki, Harukazu, Brombacher, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366092/
https://ncbi.nlm.nih.gov/pubmed/25790379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121070
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