Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri

Oxidative stress induced by reactive oxygen species (ROS) increases during lifespan and is involved in aging processes. The p66Shc adaptor protein is a master regulator of oxidative stress response in mammals. Ablation of p66Shc enhances oxidative stress resistance both in vitro and in vivo. Most im...

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Dades bibliogràfiques
Publicat a:Aging Dis
Autors principals: Priami, Chiara, De Michele, Giulia, Cotelli, Franco, Cellerino, Alessandro, Giorgio, Marco, Pelicci, Pier Giuseppe, Migliaccio, Enrica
Format: Artigo
Idioma:Inglês
Publicat: JKL International LLC 2015
Matèries:
Review Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365960/
https://ncbi.nlm.nih.gov/pubmed/25821638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2014.0228
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