Dysregulated serum response factor triggers formation of hepatocellular carcinoma

The ubiquitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MAPK (mitogen-activated protein kinase) and Rho/actin signaling pathways, which are frequently activated in hepatocellular carcinoma (HCC). We generated SRF-VP16(iHep) mice, which conditionally...

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Veröffentlicht in:Hepatology
Hauptverfasser: Ohrnberger, Stefan, Thavamani, Abhishek, Braeuning, Albert, Lipka, Daniel B, Kirilov, Milen, Geffers, Robert, Authenrieth, Stella E, Römer, Michael, Zell, Andreas, Bonin, Michael, Schwarz, Michael, Schütz, Günther, Schirmacher, Peter, Plass, Christoph, Longerich, Thomas, Nordheim, Alfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Hepatobiliary Malignancies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365683/
https://ncbi.nlm.nih.gov/pubmed/25266280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27539
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