Direct Site-Specific Glycoform Identification and Quantitative Comparison of Glycoprotein Therapeutics: Imiglucerase and Velaglucerase Alfa

Gaucher disease, the most common lysosomal metabolic disorder, can be treated with enzyme replacement therapy (ERT). Recombinant human glucocerebrosidase imiglucerase (Cerezyme(®)), produced in Chinese hamster ovary cells, has been used for ERT of Gaucher disease for 20 years. Another recombinant gl...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:AAPS J
Main Authors: Ye, Hongping, Hill, John, Gucinski, Ashley C., Boyne, Michael T., Buhse, Lucinda F.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365082/
https://ncbi.nlm.nih.gov/pubmed/25501675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9706-4
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