Two Arginine Residues Suppress the Flexibility of Nucleosomal DNA in the Canonical Nucleosome Core

The dynamics of nucleosomes containing either canonical H3 or its centromere-specific variant CENP-A were investigated using molecular dynamics simulations. The simulations showed that the histone cores were structurally stable during simulation periods of 100 ns and 50 ns, while DNA was highly flex...

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Udgivet i:PLoS One
Main Authors: Kono, Hidetoshi, Shirayama, Kazuyoshi, Arimura, Yasuhiro, Tachiwana, Hiroaki, Kurumizaka, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365049/
https://ncbi.nlm.nih.gov/pubmed/25786215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120635
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