Two Arginine Residues Suppress the Flexibility of Nucleosomal DNA in the Canonical Nucleosome Core

The dynamics of nucleosomes containing either canonical H3 or its centromere-specific variant CENP-A were investigated using molecular dynamics simulations. The simulations showed that the histone cores were structurally stable during simulation periods of 100 ns and 50 ns, while DNA was highly flex...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Kono, Hidetoshi, Shirayama, Kazuyoshi, Arimura, Yasuhiro, Tachiwana, Hiroaki, Kurumizaka, Hitoshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365049/
https://ncbi.nlm.nih.gov/pubmed/25786215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120635
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