Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively. Using a cell co-culture system, we found that gastric stroma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Yoshida, Junjiro, Masuda, Tohru, Yamasaki, Manabu, Usami, Ihomi, Sakamoto, Shuichi, Abe, Hikaru, Watanabe, Takumi, Yamori, Takao, Shibasaki, Masakatsu, Nomoto, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364666/
https://ncbi.nlm.nih.gov/pubmed/25785838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119415
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