Directionality of temperature-activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six

Several transient receptor potential (TRP) ion channels are activated with high sensitivity by either cold or hot temperatures. However, structures and mechanism that determine temperature-directionality (cold vs. heat) are not established. Here we screened 12,000 random mutant clones of the cold-ac...

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Publicado en:Neuron
Main Authors: Jabba, Sairam, Goyal, Raman, Sosa-Pagán, Jason O., Moldenhauer, Hans, Wu, Jason, Kalmeta, Breanna, Bandell, Michael, Latorre, Ramon, Patapoutian, Ardem, Grandl, Jörg
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364554/
https://ncbi.nlm.nih.gov/pubmed/24814535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.04.016
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