An underlying mechanism for the increased mutagenesis of lagging-strand genes in Bacillus subtilis

We previously reported that lagging-strand genes accumulate mutations faster than those encoded on the leading strand in Bacillus subtilis. Although we proposed that orientation-specific encounters between replication and transcription underlie this phenomenon, the mechanism leading to the increased...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Million-Weaver, Samuel, Samadpour, Ariana N., Moreno-Habel, Daniela A., Nugent, Patrick, Brittnacher, Mitchell J., Weiss, Eli, Hayden, Hillary S., Miller, Samuel I., Liachko, Ivan, Merrikh, Houra
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364195/
https://ncbi.nlm.nih.gov/pubmed/25713353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416651112
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