Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca(2+)-permeable AMPA receptors

Gene knockout (KO) does not always result in phenotypic changes, possibly due to mechanisms of functional compensation. We have studied mice lacking cGMP-dependent kinase II (cGKII), which phosphorylates GluA1, a subunit of AMPA receptors (AMPARs), and promotes hippocampal long-term potentiation (LT...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kim, Seonil, Titcombe, Roseann F., Zhang, Hong, Khatri, Latika, Girma, Hiwot K., Hofmann, Franz, Arancio, Ottavio, Ziff, Edward B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364185/
https://ncbi.nlm.nih.gov/pubmed/25713349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417498112
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