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Ribosomes slide on lysine-encoding homopolymeric A stretches

Protein output from synonymous codons is thought to be equivalent if appropriate tRNAs are sufficiently abundant. Here we show that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA codons into an ORF diminishes protein expression m...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Koutmou, Kristin S, Schuller, Anthony P, Brunelle, Julie L, Radhakrishnan, Aditya, Djuranovic, Sergej, Green, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363877/
https://ncbi.nlm.nih.gov/pubmed/25695637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05534
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