The C-Terminal Heavy-Chain Domain of Botulinum Neurotoxin A Is Not the Only Site That Binds Neurons, as the N-Terminal Heavy-Chain Domain Also Plays a Very Active Role in Toxin-Cell Binding and Interactions

Botulinum neurotoxins (BoNTs) possess unique specificity for nerve terminals. They bind to the presynaptic membrane and then translocate intracellularly, where the light-chain endopeptidase cleaves the SNARE complex proteins, subverting the synaptic exocytosis responsible for acetylcholine release t...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Ayyar, B. Vijayalakshmi, Aoki, K. Roger, Atassi, M. Zouhair
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363415/
https://ncbi.nlm.nih.gov/pubmed/25624352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00063-15
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