Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites

Antigen-mediated crosslinking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcεRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also express FcεRI that is constitutively occupied with IgE. In contrast to mast cell...

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Publié dans:Mucosal Immunol
Auteurs principaux: Platzer, Barbara, Baker, Kristi, Vera, Miguel Pinilla, Singer, Kathleen, Panduro, Marisella, Lexmond, Willem S., Turner, Devin, Vargas, Sara O., Kinet, Jean-Pierre, Maurer, Dieter, Baron, Rebecca M., Blumberg, Richard S., Fiebiger, Edda
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363306/
https://ncbi.nlm.nih.gov/pubmed/25227985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.85
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