Highly Potent and Selective Ectonucleotide Pyrophosphatase/Phosphodiesterase I Inhibitors Based on an Adenosine 5′-(α or γ)- Thio-(α,β- or β,γ)-methylenetriphosphate Scaffold

[Image: see text] Aberrant nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) activity is associated with chondrocalcinosis, osteoarthritis, and type 2 diabetes. The potential of NPP1 inhibitors as therapeutic agents, and the scarceness of their structure–activity relationship, encouraged us to d...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Nadel, Yael, Lecka, Joanna, Gilad, Yocheved, Ben-David, Gal, Förster, Daniel, Reiser, Georg, Kenigsberg, Sarah, Camden, Jean, Weisman, Gary A., Senderowitz, Hanoch, Sévigny, Jean, Fischer, Bilha
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363092/
https://ncbi.nlm.nih.gov/pubmed/24846781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500196c
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