Nonclinical Evaluation of Novel Cationically Modified Polysaccharide Antidotes for Unfractionated Heparin

Protamine, the only registered antidote of unfractionated heparin (UFH), may produce a number of adverse effects, such as anaphylactic shock or serious hypotension. We aimed to develop an alternative UFH antidote as efficient as protamine, but safer and easier to produce. As a starting material, we...

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Publicado en:PLoS One
Main Authors: Kalaska, Bartlomiej, Kaminski, Kamil, Sokolowska, Emilia, Czaplicki, Dominik, Kujdowicz, Monika, Stalinska, Krystyna, Bereta, Joanna, Szczubialka, Krzysztof, Pawlak, Dariusz, Nowakowska, Maria, Mogielnicki, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362941/
https://ncbi.nlm.nih.gov/pubmed/25781030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119486
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