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Activity-dependent degeneration of axotomized neuromuscular synapses in Wld(S) mice

Activity and disuse of synapses are thought to influence progression of several neurodegenerative diseases in which synaptic degeneration is an early sign. Here we tested whether stimulation or disuse renders neuromuscular synapses more or less vulnerable to degeneration, using axotomy as a robust t...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Brown, R., Hynes-Allen, A., Swan, A.J., Dissanayake, K.N., Gillingwater, T.H., Ribchester, R.R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362769/
https://ncbi.nlm.nih.gov/pubmed/25617654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.01.018
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