Inhibitor and Substrate Binding Induced Stability of HIV-1 Protease against Sequential Dissociation and Unfolding Revealed by High Pressure Spectroscopy and Kinetics

High-pressure methods have become an interesting tool of investigation of structural stability of proteins. They are used to study protein unfolding, but dissociation of oligomeric proteins can be addressed this way, too. HIV-1 protease, although an interesting object of biophysical experiments, has...

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Vydáno v:PLoS One
Hlavní autoři: Ingr, Marek, Lange, Reinhard, Halabalová, Věra, Yehya, Alaa, Hrnčiřík, Josef, Chevalier-Lucia, Dominique, Palmade, Laetitia, Blayo, Claire, Konvalinka, Jan, Dumay, Eliane
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362767/
https://ncbi.nlm.nih.gov/pubmed/25781460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119099
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