Inhibitor and Substrate Binding Induced Stability of HIV-1 Protease against Sequential Dissociation and Unfolding Revealed by High Pressure Spectroscopy and Kinetics

High-pressure methods have become an interesting tool of investigation of structural stability of proteins. They are used to study protein unfolding, but dissociation of oligomeric proteins can be addressed this way, too. HIV-1 protease, although an interesting object of biophysical experiments, has...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ingr, Marek, Lange, Reinhard, Halabalová, Věra, Yehya, Alaa, Hrnčiřík, Josef, Chevalier-Lucia, Dominique, Palmade, Laetitia, Blayo, Claire, Konvalinka, Jan, Dumay, Eliane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362767/
https://ncbi.nlm.nih.gov/pubmed/25781460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119099
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