Deregulation of sertoli and leydig cells function in patients with klinefelter syndrome as evidenced by testis transcriptome analysis

BACKGROUND: Klinefelter Syndrome (KS) is the most common abnormality of sex chromosomes (47,XXY) and represents the first genetic cause of male infertility. Mechanisms leading to KS testis degeneration are still not completely defined but considered to be mainly the result of germ cells loss. In ord...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: D’Aurora, Marco, Ferlin, Alberto, Di Nicola, Marta, Garolla, Andrea, De Toni, Luca, Franchi, Sara, Palka, Giandomenico, Foresta, Carlo, Stuppia, Liborio, Gatta, Valentina
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362638/
https://ncbi.nlm.nih.gov/pubmed/25879484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1356-0
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