HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells

The Bcr-Abl protein is an important client protein of heat shock protein 90 (HSP90). We evaluated the inhibitory effects of the HSP90 ATPase inhibitor AUY922 on 32D mouse hematopoietic cells expressing wild-type Bcr-Abl (b3a2, 32Dp210) and mutant Bcr-Abl imatinib (IM)-resistant cell lines. Western b...

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Detalles Bibliográficos
Publicado en:Genes Cancer
Main Authors: Tao, Wenjing, Chakraborty, Sandip N., Leng, Xiaohong, Ma, Helen, Arlinghaus, Ralph B.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362481/
https://ncbi.nlm.nih.gov/pubmed/25821558
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