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Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9

Efficient gene transfer to muscle stem cells (satellite cells) has not been achieved despite broad transduction of skeletal muscle by systemically administered adeno-associated virus serotype 2/9 (AAV-9) in mice. We hypothesized that cellular migration during fetal development would make satellite c...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Stitelman, David H, Brazelton, Tim, Bora, Archana, Traas, Jeremy, Merianos, Demetri, Limberis, Maria, Davey, Marcus, Flake, Alan W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362369/
https://ncbi.nlm.nih.gov/pubmed/26015979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.40
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