Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

Sustained gene delivery of interferon (IFN) γ can be an effective treatment, but our previous study showed high levels of IFNγ-induced adverse events, including the loss of body weight. These unwanted events could be reduced by target-specific delivery of IFNγ after in vivo gene transfer. To achieve...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Ando, Mitsuru, Takahashi, Yuki, Yamashita, Takuma, Fujimoto, Mai, Nishikawa, Makiya, Watanabe, Yoshihiko, Takakura, Yoshinobu
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362348/
https://ncbi.nlm.nih.gov/pubmed/26015966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.23
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