Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson’s disease patients

BACKGROUND. Recombinant human PDGF-BB (rhPDGF-BB) reduces Parkinsonian symptoms and increases dopamine transporter (DAT) binding in several animal models of Parkinson’s disease (PD). Effects of rhPDGF-BB are the result of proliferation of ventricular wall progenitor cells and reversed by blocking mi...

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Pubblicato in:J Clin Invest
Autori principali: Paul, Gesine, Zachrisson, Olof, Varrone, Andrea, Almqvist, Per, Jerling, Markus, Lind, Göran, Rehncrona, Stig, Linderoth, Bengt, Bjartmarz, Hjalmar, Shafer, Lisa L., Coffey, Robert, Svensson, Mikael, Mercer, Katarina Jansson, Forsberg, Anton, Halldin, Christer, Svenningsson, Per, Widner, Håkan, Frisén, Jonas, Pålhagen, Sven, Haegerstrand, Anders
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362250/
https://ncbi.nlm.nih.gov/pubmed/25689258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79635
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