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Relative performance of two-stage continual reassessment method in contrast to an optimal benchmark

BACKGROUND: The two-stage, likelihood-based continual reassessment method (CRM-L; O’Quigley and Shen [1]) entails the specification of a set of design parameters prior to the beginning of its use in a study. The impression of clinicians is that the success of model-based designs, such as CRM-L, depe...

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Bibliographic Details
Published in:Clin Trials
Main Authors: Wages, Nolan A., Conaway, Mark R., O’Quigley, John
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361948/
https://ncbi.nlm.nih.gov/pubmed/24085776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774513503521
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