Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient survival. The concept of synthetic lethality, brought about by inactivating complementary DNA repair pathways, has been proposed as a promising...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Boerner, Julie L., Nechiporchik, Nicole, Mueller, Kelly L., Polin, Lisa, Heilbrun, Lance, Boerner, Scott A., Zoratti, Gina L., Stark, Karri, LoRusso, Patricia M., Burger, Angelika
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361640/
https://ncbi.nlm.nih.gov/pubmed/25774912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119614
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