Double NF1 Inactivation Affects Adrenocortical Function in NF1Prx1 Mice and a Human Patient

BACKGROUND: Neurofibromatosis type I (NF1, MIM#162200) is a relatively frequent genetic condition, which predisposes to tumor formation. Apart from tumors, individuals with NF1 often exhibit endocrine abnormalities such as precocious puberty (2,5–5% of NF1 patients) and some cases of hypertension (1...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Kobus, Karolina, Hartl, Daniela, Ott, Claus Eric, Osswald, Monika, Huebner, Angela, von der Hagen, Maja, Emmerich, Denise, Kühnisch, Jirko, Morreau, Hans, Hes, Frederik J., Mautner, Victor F., Harder, Anja, Tinschert, Sigrid, Mundlos, Stefan, Kolanczyk, Mateusz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361563/
https://ncbi.nlm.nih.gov/pubmed/25775093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119030
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