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Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
The SPOP E3 ubiquitin ligase gene is frequently mutated in human prostate cancers. Here, we demonstrate that SPOP recognizes a Ser/Thr-rich degron in the hinge domain of androgen receptor (AR)and induces degradation of full-length AR and inhibition of AR-mediated gene transcription and prostate canc...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361392/ https://ncbi.nlm.nih.gov/pubmed/24508459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.013 |
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