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Ru binding to RNA following treatment with the antimetastatic prodrug NAMI-A in Saccharomyces cerevisiae and in vitro

[ImH][trans-Ru(III)Cl(4)(DMSO)(Im)] (where DMSO is dimethyl sulfoxide and Im is imidazole) (NAMI-A) is an antimetastatic prodrug currently in phase II clinical trials. The mechanisms of action of this and related Ru-based anticancer agents are not well understood, but several cellular targets have b...

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Detalhes bibliográficos
Publicado no:J Biol Inorg Chem
Main Authors: Hostetter, Alethia A., Miranda, Michelle L., DeRose, Victoria J., Holman, Karen L. McFarlane
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361230/
https://ncbi.nlm.nih.gov/pubmed/21739255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-011-0806-7
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