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Characterization of RNA-Pt Adducts Formed from Cisplatin Treatment of Saccharomyces cerevisiae

The numerous regulatory roles of cellular RNAs suggest novel potential drug targets, but establishing intracellular drug-RNA interactions is challenging. Cisplatin (cis-diamminedichloridoplatinum(II)) is a leading anticancer drug that forms exchange-inert complexes with nucleic acids, allowing its d...

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Bibliographic Details
Main Authors: Hostetter, Alethia A., Osborn, Maire F., DeRose, Victoria J.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262962/
https://ncbi.nlm.nih.gov/pubmed/22004017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200279p
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