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Characterization of RNA-Pt Adducts Formed from Cisplatin Treatment of Saccharomyces cerevisiae
The numerous regulatory roles of cellular RNAs suggest novel potential drug targets, but establishing intracellular drug-RNA interactions is challenging. Cisplatin (cis-diamminedichloridoplatinum(II)) is a leading anticancer drug that forms exchange-inert complexes with nucleic acids, allowing its d...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262962/ https://ncbi.nlm.nih.gov/pubmed/22004017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200279p |
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