Epigenetic Therapy for Friedreich Ataxia

OBJECTIVE: To investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients. METHODS: We used a human FRDA...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Ann Neurol
Huvudupphovsmän: Soragni, Elisabetta, Miao, Wenyan, Iudicello, Marco, Jacoby, David, De Mercanti, Stefania, Clerico, Marinella, Longo, Filomena, Piga, Antonio, Ku, Sherman, Campau, Erica, Du, Jintang, Penalver, Pablo, Rai, Myriam, Madara, Joseph C., Nazor, Kristopher, O’Connor, Melinda, Maximov, Anton, Loring, Jeanne F., Pandolfo, Massimo, Durelli, Luca, Gottesfeld, Joel M., Rusche, James R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361037/
https://ncbi.nlm.nih.gov/pubmed/25159818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24260
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk