L-Asparaginase II Produced by Salmonella Typhimurium Inhibits T Cell Responses and Mediates Virulence

Salmonella enterica serovar Typhimurium avoids clearance by the host immune system by suppressing T cell responses; however, the mechanisms that mediate this immunosuppression remain unknown. We show that S. Typhimurium inhibit T cell responses by producing L-Asparaginase II, which catalyzes the hyd...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Kullas, Amy L., McClelland, Michael, Yang, Hee-Jeong, Tam, Jason W., Torres, AnnMarie, Porwollik, Steffen, Mena, Patricio, McPhee, Joseph B., Bogomolnaya, Lydia, Andrews-Polymenis, Helene, van der Velden, Adrianus W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361029/
https://ncbi.nlm.nih.gov/pubmed/23245323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.10.018
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