SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice

Superoxide dismutase (SOD) is a major defender against excessive superoxide generated under hyperglycemia. We have recently reported that renal SOD1 (cytosolic CuZn-SOD) and SOD3 (extracellular CuZn-SOD) isoenzymes are remarkably down-regulated in KK/Ta-Ins2(Akita) diabetic mice, which exhibit progr...

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Publicado en:Metabolism
Autores principales: Fujita, Hiroki, Fujishima, Hiromi, Takahashi, Keiko, Sato, Takehiro, Shimizu, Tatsunori, Morii, Tsukasa, Shimizu, Takahiko, Shirasawa, Takuji, Qi, Zhonghua, Breyer, Matthew D., Harris, Raymond C., Yamada, Yuichiro, Takahashi, Takamune
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360989/
https://ncbi.nlm.nih.gov/pubmed/22632894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2012.05.005
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