Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice

Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and the superoxide-scavenging enzyme superoxide dismutase (SOD) under hyperglycemia, increases oxidative stress and contributes to the development of diabetic nephropathy. In this study, we t...

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Main Authors: Fujita, Hiroki, Fujishima, Hiromi, Morii, Tsukasa, Sakamoto, Takuya, Komatsu, Koga, Hosoba, Mihoko, Narita, Takuma, Takahashi, Keiko, Takahashi, Takamune, Yamada, Yuichiro
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273720/
https://ncbi.nlm.nih.gov/pubmed/22072110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/hr.2011.176
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