Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

Doxorubicin is a highly effective anti-cancer chemotherapy agent, but its usage is limited by its cardiotoxicity. To develop a drug that prevents the cardiac toxicity of doxorubicin while preserving its anti-tumor potency, we established a doxorubicin-induced cardiomyopathy model in zebrafish that r...

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Publié dans:Sci Transl Med
Auteurs principaux: Liu, Yan, Asnani, Aarti, Zou, Lin, Bentley, Victoria L., Yu, Min, Wang, You, Dellaire, Graham, Sarkar, Kumar S., Dai, Matthew, Chen, Howard H., Sosnovik, David E., Shin, Jordan T., Haber, Daniel A., Berman, Jason N., Chao, Wei, Peterson, Randall T.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360984/
https://ncbi.nlm.nih.gov/pubmed/25504881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010189
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