Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

Doxorubicin is a highly effective anti-cancer chemotherapy agent, but its usage is limited by its cardiotoxicity. To develop a drug that prevents the cardiac toxicity of doxorubicin while preserving its anti-tumor potency, we established a doxorubicin-induced cardiomyopathy model in zebrafish that r...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Liu, Yan, Asnani, Aarti, Zou, Lin, Bentley, Victoria L., Yu, Min, Wang, You, Dellaire, Graham, Sarkar, Kumar S., Dai, Matthew, Chen, Howard H., Sosnovik, David E., Shin, Jordan T., Haber, Daniel A., Berman, Jason N., Chao, Wei, Peterson, Randall T.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360984/
https://ncbi.nlm.nih.gov/pubmed/25504881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010189
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