Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model

Doxorubicin is a highly effective chemotherapy agent used to treat many common malignancies. However, its use is limited by cardiotoxicity, and cumulative doses exponentially increase the risk of heart failure. To identify novel heart failure treatment targets, we previously established a zebrafish...

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Vydáno v:Chembiochem
Hlavní autoři: Lam, Pui-Ying, Kutchukian, Peter, Anand, Rajan, Imbriglio, Jason, Andrews, Christine, Padilla, Hugo, Vohra, Anita, Lane, Sarah, Parker, Dann L., Taracido, Ivan Cornella, Johns, Douglas G., Beerens, Manu, MacRae, Calum A., Caldwell, John, Sorota, Steve, Asnani, Aarti, Peterson, Randall T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500981/
https://ncbi.nlm.nih.gov/pubmed/32003101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900741
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