Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

Oligodendrocyte death contributes to the pathogenesis of the inflammatory demyelinating disease multiple sclerosis (MS). Nevertheless, current MS therapies are mainly immunomodulatory and have demonstrated limited ability to inhibit MS progression. Protection of oligodendrocytes is therefore a desir...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Way, Sharon W., Podojil, Joseph R., Clayton, Benjamin L., Zaremba, Anita, Collins, Tassie L., Kunjamma, Rejani B., Robinson, Andrew P., Brugarolas, Pedro, Miller, Robert H., Miller, Stephen D., Popko, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360920/
https://ncbi.nlm.nih.gov/pubmed/25766071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7532
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