Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients

T cell responses to allogeneic major histocompatibility (MHC) antigens present a formidable barrier to organ transplantation, necessitating long-term immunosuppression to minimize rejection. Chronic rejection and drug-induced morbidities are major limitations that could be overcome by allograft tole...

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Pubblicato in:Sci Transl Med
Autori principali: Morris, Heather, DeWolf, Susan, Robins, Harlan, Sprangers, Ben, LoCascio, Samuel A., Shonts, Brittany A., Kawai, Tatsuo, Wong, Waichi, Yang, Suxiao, Zuber, Julien, Shen, Yufeng, Sykes, Megan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360892/
https://ncbi.nlm.nih.gov/pubmed/25632034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010760
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