Graded Ca(2+)/calmodulin-dependent coupling of voltage-gated Ca(V)1.2 channels

In the heart, reliable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple Ca(V)1.2 channels. Yet the mechanisms that coordinate this simultaneous opening during every heartbeat are unclear. Here...

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Bibliographic Details
Published in:eLife
Main Authors: Dixon, Rose E, Moreno, Claudia M, Yuan, Can, Opitz-Araya, Ximena, Binder, Marc D, Navedo, Manuel F, Santana, Luis F
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360655/
https://ncbi.nlm.nih.gov/pubmed/25714924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05608
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