Graded Ca(2+)/calmodulin-dependent coupling of voltage-gated Ca(V)1.2 channels

In the heart, reliable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple Ca(V)1.2 channels. Yet the mechanisms that coordinate this simultaneous opening during every heartbeat are unclear. Here...

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Udgivet i:eLife
Main Authors: Dixon, Rose E, Moreno, Claudia M, Yuan, Can, Opitz-Araya, Ximena, Binder, Marc D, Navedo, Manuel F, Santana, Luis F
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360655/
https://ncbi.nlm.nih.gov/pubmed/25714924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05608
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