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Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells
Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...
Shranjeno v:
| izdano v: | eLife |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360653/ https://ncbi.nlm.nih.gov/pubmed/25781344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05875 |
| Oznake: |
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