ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling

Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast can...

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Udgivet i:Sci Rep
Main Authors: Masuda, Tetsuro, Endo, Motoyoshi, Yamamoto, Yutaka, Odagiri, Haruki, Kadomatsu, Tsuyoshi, Nakamura, Takayuki, Tanoue, Hironori, Ito, Hitoshi, Yugami, Masaki, Miyata, Keishi, Morinaga, Jun, Horiguchi, Haruki, Motokawa, Ikuyo, Terada, Kazutoyo, Morioka, Masaki Suimye, Manabe, Ichiro, Iwase, Hirotaka, Mizuta, Hiroshi, Oike, Yuichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360633/
https://ncbi.nlm.nih.gov/pubmed/25773070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09170
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