Synthesis and Evaluation of Conjugates of Novel TLR7 Inert Ligands as Self-Adjuvanting Immunopotentiators

[Image: see text] During the design and synthesis of a series of 8-hydroxy-2-(2-methoxyethoxy)-adenine derivatives bearing various substituted −RCOOH groups at the 9-position, we identified a TLR7-inert ligand, which does not activate TLR7 signaling pathway. Of interest, the coupling of weakly immun...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Gao, Dong, Liu, Yu, Diao, Yuwen, Gao, Ningning, Wang, Zhulin, Jiang, Wenqi, Jin, Guangyi
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360170/
https://ncbi.nlm.nih.gov/pubmed/25815141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003647
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