Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors

[Image: see text] A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the phenyl ring pending from the triazole. The...

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Publicat a:ACS Med Chem Lett
Autors principals: Rombouts, Frederik J. R., Tresadern, Gary, Buijnsters, Peter, Langlois, Xavier, Tovar, Fulgencio, Steinbrecher, Thomas B., Vanhoof, Greet, Somers, Marijke, Andrés, José-Ignacio, Trabanco, Andrés A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360147/
https://ncbi.nlm.nih.gov/pubmed/25815146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500463t
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