Llwytho...
Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors
[Image: see text] A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the phenyl ring pending from the triazole. The...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Med Chem Lett |
|---|---|
| Prif Awduron: | , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical
Society
2015
|
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360147/ https://ncbi.nlm.nih.gov/pubmed/25815146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500463t |
| Tagiau: |
Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|