Improved Angiostatic Activity of Dasatinib by Modulation with Hydrophobic Chains

[Image: see text] Dasatinib is an orally active nonselective tyrosine kinase inhibitor used to treat certain types of adult leukemia. By inhibiting PDGFR-β and SFKs in both tumor cells and tumor-associated endothelial cells, dasatinib inhibits tumor growth and angiogenesis. Herein, dasatinib derivat...

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Publicat a:ACS Med Chem Lett
Autors principals: Păunescu, Emilia, Clavel, Catherine M., Nowak-Sliwinska, Patrycja, Griffioen, Arjan W., Dyson, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360145/
https://ncbi.nlm.nih.gov/pubmed/25815152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500496u
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