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Improved Angiostatic Activity of Dasatinib by Modulation with Hydrophobic Chains
[Image: see text] Dasatinib is an orally active nonselective tyrosine kinase inhibitor used to treat certain types of adult leukemia. By inhibiting PDGFR-β and SFKs in both tumor cells and tumor-associated endothelial cells, dasatinib inhibits tumor growth and angiogenesis. Herein, dasatinib derivat...
Enregistré dans:
| Publié dans: | ACS Med Chem Lett |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Chemical
Society
2015
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360145/ https://ncbi.nlm.nih.gov/pubmed/25815152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500496u |
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