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An angiotensin-(1–7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin-degrading enzyme

Angiotensin 1–7 [ANG-(1–7)] is expressed within the kidney and exhibits renoprotective actions that antagonize the inflammatory, fibrotic, and pro-oxidant effects of ANG II. We previously identified an peptidase that preferentially metabolized ANG-(1–7) to ANG-(1–4) in the brain medulla and cerebros...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Wilson, Bryan A., Cruz-Diaz, Nildris, Marshall, Allyson C., Pirro, Nancy T., Su, Yixin, Gwathmey, TanYa M., Rose, James C., Chappell, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360035/
https://ncbi.nlm.nih.gov/pubmed/25568136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00609.2014
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