Comparing variant calling algorithms for target-exon sequencing in a large sample

BACKGROUND: Sequencing studies of exonic regions aim to identify rare variants contributing to complex traits. With high coverage and large sample size, these studies tend to apply simple variant calling algorithms. However, coverage is often heterogeneous; sites with insufficient coverage may benef...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Bioinformatics
Main Authors: Lo, Yancy, Kang, Hyun M, Nelson, Matthew R, Othman, Mohammad I, Chissoe, Stephanie L, Ehm, Margaret G, Abecasis, Gonçalo R, Zöllner, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359451/
https://ncbi.nlm.nih.gov/pubmed/25884587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0489-0
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki