Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reducti...

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Pubblicato in:Oncotarget
Autori principali: Cusimano, Antonella, Puleio, Roberto, D'Alessandro, Natale, Loria, Guido R., McCubrey, James A., Montalto, Giuseppe, Cervello, Melchiorre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359326/
https://ncbi.nlm.nih.gov/pubmed/25596737
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