Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reducti...

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Udgivet i:Oncotarget
Main Authors: Cusimano, Antonella, Puleio, Roberto, D'Alessandro, Natale, Loria, Guido R., McCubrey, James A., Montalto, Giuseppe, Cervello, Melchiorre
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359326/
https://ncbi.nlm.nih.gov/pubmed/25596737
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