Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells

Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Cel...

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Main Authors: Cervello, Melchiorre, Bachvarov, Dimcho, Lampiasi, Nadia, Cusimano, Antonella, Azzolina, Antonina, McCubrey, James A., Montalto, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680460/
https://ncbi.nlm.nih.gov/pubmed/23776502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065569
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